By Bradley S. Fleenor, Adam J. Berrones
Read Online or Download Arterial Stiffness: Implications and Interventions PDF
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Extra info for Arterial Stiffness: Implications and Interventions
Interventions focused on attenuating adventitial TGF-β1 signaling may be of importance as the adventitia is a key load-bearing layer of arteries. Advanced Glycation End-Products (AGEs) As discussed previously, AGEs are responsible for cross-linking extracellular proteins that ultimately contribute to aortic stiffness. Notably, AGEs also bind the receptor of advanced glycation end-products (RAGE) which results in intracellular signaling that promotes negative biological consequences such as greater arterial stiffness seen with aging .
Huynh Q, Blizzard L, Sharman J, Magnussen C, Schmidt M, Dwyer T, Venn A (2013) Relative contributions of adiposity in childhood and adulthood to vascular health of young adults. Atherosclerosis 228(1):259–264. 022 40. Orr JS, Gentile CL, Davy BM, Davy KP (2008) Large artery stiffening with weight gain in humans: role of visceral fat accumulation. Hypertension 51(6):1519–1524. 112946 41. Schouten F, Twisk JW, de Boer MR, Stehouwer CD, Serne EH, Smulders YM, Ferreira I (2011) Increases in central fat mass and decreases in peripheral fat mass are associated with accelerated arterial stiffening in healthy adults: the Amsterdam Growth and Health Longitudinal Study.
For example, discrepancies exist between sexes regarding atherosclerosis, hypertension, angina, and stroke . Therefore, predicting CVD risk in women is challenging because many statistical models of cardiovascular complications relying on traditional risk factors such as smoking, diabetes, and total cholesterol, have not accounted for sex differences that are known to exist . Older women compared with aged men have a greater incidence of heart failure with preserved ejection fraction (HFpEF).
Arterial Stiffness: Implications and Interventions by Bradley S. Fleenor, Adam J. Berrones
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