By Michel E. Safar, Edward D. Frohlich
This booklet offers the present taking into account overseas specialists concerning the underlying mechanisms of cardiovascular chance in addition to the pathogenesis and pathophysiology of impaired huge arterial stiffness and lowered huge arterial distensibility. It additionally demonstrates the explanation for the current method of the administration and therapy of hypertensive illnesses and atherosclerosis. The distinctive readership contains easy scientists in vascular body structure in addition to physicians and scientists in cardiovascular medication, diabetes mellitus and renal ailments.
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Additional resources for Atherosclerosis, large arteries and cardiovascular risk
Arterioscler Thromb Vasc Biol 2004;24:782–786. Mitchell GF, Izzo JL Jr, Lacourciere Y, Ouellet JP, Neutel J, Qian C, Kerwin LJ, Block AJ, Pfeffer MA: Omapatrilat reduces pulse pressure and proximal aortic stiffness in patients with systolic hypertension: results of the conduit hemodynamics of omapatrilat international research study. Circulation 2002;105:2955–2961. Kass DA, Shapiro EP, Kawaguchi M, Capriotti AR, Scuteri A, deGroof RC, Lakatta EG: Improved arterial compliance by a novel advanced glycation end-product crosslink breaker.
42] proposed a method to measure the elasticity (strain and modulus) of biological tissues using ultrasound. The tissue was deformed by externally applying a stress on it. Different strain values were found in tissues with different material properties. Implementing this method for intravascular purposes has potential to identify the vulnerable plaque by (i) identification of elastically different plaque components and (ii) detection of high radial strain/circumferential stress regions. Imaging Local Plaque Elasticity 41 This chapter discusses the technique behind the method for and the validation of IVUS strain elastography, which is differentiated into IVUS strain elastography/palpography when the strain is imaged and IVUS modulus elastography when the modulus is imaged.
D Calcified nodule: a section of the mid right coronary artery shows an eccentric lesion with extensive calcification (calcified plate) and surface calcified nodules with loss of fibrous cap and luminal fibrin deposition. E Inflamed thin-cap fibroatheroma: a section of a coronary artery contains a large lipid-rich core that is covered by a thin fibrous cap (arrowheads). The lumen contains contrast medium injected postmortem. The fibrous cap is severely inflamed, containing many macrophage foam cells (asterisk), and extravasated erythrocytes within the necrotic and avascular core just beneath the cap, indicating that the cap is ruptured nearby.
Atherosclerosis, large arteries and cardiovascular risk by Michel E. Safar, Edward D. Frohlich