By Donald A. Abraham
His is quantity three: Cardiovascular brokers and Endocrines, of Burger's Medicinal Chemistry and Drug Discovery, sixth version. This new quantity includes serious new chapters on Endogenous Vasoactive Peptides, Iron Chelators and healing makes use of, and basics of Steroid Chemistry and Biochemistry.
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Extra resources for Burger's Medicinal Chemistry and Drug Discovery, Cardiovascular Agents and Endocrines
6): This compound is a benzanilide derivative containing a piperidine ring. Like other class I compounds, it blocks sodium channels, depressing the upstroke velocity of phase 0 of the action potential and increasing the recovery period after repolarization (218). Encainide has also been shown to block the delayed potassium rectifier current (219). Like other class I antiarrhythmics, encainide contains a terminal tertiary amine and is formulated as a chloride salt. It is used to treat life-threatening ventricular arrhythmias.
Nifedipine is administered orally through extended release tablets in various dosage forms. It is mainly used in the treatment of Prinzmetal angina and chronic stable angina. In the latter case, it is as effective as p-adrenergic agents or oral nitrates, but is used only when the patient has low tolerability for adequate doses of these drugs. Nilvadipine (31) (Fig. 3): Nilvadipine is marketed as a racemic mixture for < 4 Antianginal Agents and Vasodilators the treatment of hypertension and angina (164-166).
13. Chemical structures of class IC antiarrhythmic agents: sodium channel blockers. and prolongs the effective refractory period relative to the action potential duration. It decreases the force of contraction, depresses pacemaker action, and improves atrioventricular conduction, especially when administered in conjunction with digitalis (217). 3 Class IC Antiarrhythmics. Encainide (42) (Fig. 6): This compound is a benzanilide derivative containing a piperidine ring. Like other class I compounds, it blocks sodium channels, depressing the upstroke velocity of phase 0 of the action potential and increasing the recovery period after repolarization (218).
Burger's Medicinal Chemistry and Drug Discovery, Cardiovascular Agents and Endocrines by Donald A. Abraham